Supporting Research
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Andersen S, Petersen KM, Brunn NH, Laurberg P (2002). Narrow individual variations in serum T4 and T3 in normal subjects: a clue to the understanding of subclinical thyroid disease. Journal of Clinical Endocrinology and Metabolism. 2002;87:1068– 72. Abstract: High individuality causes laboratory reference ranges to be insensitive to changes in test results that are significant for the individual. Our data indicate that each individual had a unique thyroid function. The individual reference ranges for test results were narrow, compared with group reference ranges used to develop laboratory reference ranges. Accordingly, a test result within laboratory reference limits is not necessarily normal for an individual. Our data indicate that the distinction between subclinical and overt thyroid disease (abnormal serum TSH and abnormal T4 and/or T3) is somewhat arbitrary.
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